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KMID : 0043319920150010001
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Archives of Pharmacal Research
1992 Volume.15 No. 1 p.1 ~ p.4
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Synthesis of Some New 4-Substituted Antipyrines as Potential Antipyretic Analgesics
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Hammouda M
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Abstract
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4-Acetylantipyrine 1 underwent condensation with 4-formyl-antipyrine 2 to give 3. Condensation of either 3 with 1 or 1 with 2 in a molar ratio of (2: 1) afforded 4. Cyclization of 4 in the presence of PPA and ammonium acetate or 4-aminoantipyrine in the presence of glacial acetic acid gave 5-7, respectively. Claisen condensation of I with ethyl acetate and diethyl oxalate afforded compounds 8-10. The reaction of 1 and 2 with indole in ethanol/conc. hydrochloric acid was also investigated.
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KEYWORD
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